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1998] activate apoptosis in a manner that is inhibitable by DFF45, but is independent of Caspases.Fillingim, R. 5 to 10 mg three times daily; with (three to eight times daily). 284 SECTION IV IMMUNOLOGY Stem-cell generation Lineage commitment Table 32-1 Events in T-Cell Immune Response Repertoire generation Lineage commitment Gene intenretional Thymic differentiation Thymic selection ( or ) Extrathymic differentiation Signal transduction Cytokine secretion and response Table 32-2 Events in B-Cell Immune Response Repertoire generation Gene rearrangement Internetional trading switching Signal transduction Cytokine secretion and response Effector function MHC-presented antigen recognized by T-cell receptor Homing Signal transduction Cytokine secretion and response Target lysis Macrophage recruitment Effector function Antigen recognition Immunoglobulin secretion Complement activation Signal transduction Cytokine secretion and response Stem-cell generation Lineage commitment Process at fault Generation of stem cell Development of thymus gland Cytokine or cytokine response MHC antigen expression Expression of surface protein CD43 Expression of T-cell receptor complex Maintenance of adequate numbers of lymphocytes Defective signal transduction Table 32-3 T-Cell and Combined T- and B-Cell Disorders Defect Recombinase failure to date seen only in mice Faulty facial neural crest tissue development; related to chromosome 22 deletion γ Chain of IL-2 receptor mutated Defects in multiple cytokines; IL-2 synthesis and response, IL-1 Faulty transactivators, promoters, DNA-binding stabilizers, transporters Defect in WASP (Wiskott-Aldrich syndrome protein) CD3 ζ chain defect Mutation of ADA gene Mutation of PNP gene ZAP-70 Jak3 Mutation of ATM gene; product homologous to PI3 kinases Disease [OMIM]a Severe combined immunodeficiency internetional trading DiGeorge anomaly [188400] SCID (X-linked)[312863] Various forms of SCID[147680] Bare lymphocyte syndrome [209920,600006,1720261] Wiskott-Aldrich syndrome [30100] SCID caused by TCR defect [186780] Adenosine deaminase deficiency [102700] Nucleoside phosphorylase deficiency [164050] SCID caused by ZAP-70 defect [600802,176947] Autosomal form of SCID [600802,600173] Ataxiatelangiectasia [208900] aOMIM from Online Mendelian Inheritance in Man, OMIM (TM).

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